Gamma – GT

Gamma-glutamyltransferase (GGT) is the most sensitive indicator of hepatobiliary diseases and together with other enzymes a valuable tool for the differential diagnosis in liver diseases.

Reference Ranges

Modified after Szasz
Women< 32 U/L< 0.53 µkat/L
Men< 49 U/L< 0.82 µkat/L
IFCC International Federation of Clinical Chemistry and Laboratory Medicine
Women< 38 U/L< 0.63 µkat/L
Men< 55 U/L< 0.92 µkat/L
Children / AdolescentsFemale [U/L]Female [µkat/L]Male [U/L]Male [µkat/L]
1 day – 6 months15 – 1320.250 – 2.2012 – 1220.200 – 2.03
6 months – 1 year1 – 390.017 – 0.6511 – 390.017 – 0.651
1 – 12 years4 – 220.067 – 0.3673 – 220.050 – 0.367
13 – 18 years4 – 240.067 – 0.4012 – 420.033 – 0.701
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patient’s medical history, clinical examinations and other findings.

Increased in

  1. Hepatobiliary disease
  2. History of ethanol ingestion
  3. History of drug ingestion, e.g. phenytoin, phenobarbital
  4. Pancreatitis
  5. Myocardial infarction (4 – 10 days after)
  6. Cholestasis

Conversion

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U/L
µkat/L

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