Unsaturated iron binding capacity (UIBC)

The measurement of unsaturated iron binding capacity (UIBC) in combination with serum iron is a useful diagnostic tool in the determination of various iron disorders.

Reference Ranges

120 – 470 µg/dL21 – 84 µmol/L
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patient’s medical history, clinical examinations and other findings.

Increased in

  1. Iron deficiency

Decreased in

  1. Chronic inflammatory disorders
UIBC is used for calculation of TIBC: TIBC [µg/dL] = UIBC [µg/dL] + Iron [µg/dL]


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