2021-11-09: Development project ACE - for reliable sarcoidosis diagnostics

Sarcoidosis, also known as Boeck's disease, is a rare inflammatory systemic disease that preferentially affects the lungs but may also affect other organs of the body and is characterized by an excessive inflammatory response. Sarcoidosis is prevalent all over the world. The incidence depends on age, gender, ethnic background and geographical origin. It usually appears between the age of 20 and 40 and affects women more frequently. Sarcoidosis is often an incidental diagnosis, as affected individuals often show no or hardly any symptoms.

In addition to classical inflammatory markers such as CRP and erythrocyte sedimentation rate, angiotensin converting enzyme (ACE), an activity marker of the disease, plays an essential role in the diagnosis, follow-up and treatment monitoring of sarcoidosis.

In order to improve sarcoidosis diagnostics significantly, the research and development department of DiaSys develops a modern and robust determination method for ACE. The assay, which is developed as a liquid-stable 2-component reagent with matched calibrators and controls that are also liquid-stable, is intended to determine the enzyme ACE in human samples. The easy to use, environmentally friendly and reliable determination of the enzyme ACE offers many advantages over methods available in the market and thus allows a reliable monitoring of patients.

The development of the clinical chemistry test for ACE determination is funded by the Ministry of Science of Rhineland-Palatinate within the framework of the European Regional Development Fund (ERDF). More information: www.efre.rlp.de