2022-10-07: Total bile acids 21 FS - from now on also applicable for human stool samples

Irritable bowel syndrome with diarrhea (IBS-D), bile acid diarrhea (BAD), and Crohn's disease are only a few examples of gastrointestinal tract illnesses for which TBA detection is increasingly crucial to the diagnosis. Between 25 and 50% of IBS-D patients display increased concentrations of total fecal bile acids. In addition, BAD is a frequent reason for persistent unexplained diarrhea. IBS-D and BAD are prevalent worldwide, however the 75selenium-homotaurocholic-acid-test (75SeHCAT), the current diagnostic gold standard, is not always accessible in clinical laboratories with standard procedures and analyzers. Furthermore, this test requires a seven-day timeframe, which is excessively long for a diagnostic test. Another drawback of this method is that examined patients have to ingest a radioactive substance. Alternative techniques, such gas- and liquid-chromatography-mass spectrometry, come with challenging technical procedures and require specialized equipment and correspondingly trained personnel.

In comparison, the Total bile acids 21 FS test is particularly time-efficient because it is easily applicable to various clinical chemistry analyzers. The liquid-stable DiaSys test has a long onboard and calibration stability, excellent precision and a wide measurement range (3.5 to 130 µmol/L). Moreover, our test exhibits remarkable repeatability and minimized interferences with endogenous substances that might affect the measurement. The available calibrator TruCal TBA and the multi-parameter controls TruLab N and P can be equally applied for stool diagnostics. Additionally, we provide CE-marked performance data and a comprehensive instruction for use for our DiaSys respons®910 as well as specific stool sample tube adaptors for respons®910 that significantly simplify the workflow by enabling the installation of stool sample preparation tubes directly onto the analyzer.

Download Flyer Total bile acids 21 FS (stool)