Overcoming global challenges in renal diagnostics with DiaSys

Especially for such courses of disease reliable biomarkers are essential. Cystatin C (CysC) represents such a sensitive marker, ensuring early diagnosis and treatment of kidney dysfunction. Its clear superiority over creatinine in estimating the glomerular filtration rate (GFR) has been demonstrated in several independent studies.

As mentioned in a previous DiaLog edition (53/2017) Bargnoux and co-workers demonstrated in their study that DiaSys´ Cystatin FS had by far the best performance among all tested immunoturbidimetric CysC assays³.

Besides the indispensable use of CysC in serum and plasma the clinical relevance of urinary CysC (uCysC) is of growing interest. Several studies revealed CysC in urine as a useful marker for the diagnosis of acute kidney injury (AKI) and tubular dysfunction^4,5.

Recently, Szirmay et al. 2018, validated DiaSys´ Cystatin C FS as sensitive, precise and rapid assay with a short turnaround time, therefore ideal for routine urinary CysC determinations⁶. Furthermore, Strokov and colleagues suggested urinary CysC as marker of tubular necrosis⁷ after cardiac surgery, using DiaSys´ Cystatin C FS reagent.

However, until now there was no commercially available test for measuring cystatin C in urine. DiaSys managed to overcome this lack and offers approved guideline uCysC  applications for various instruments. DiaSys´ Cystatin C FS enables the simultaneous determination of cystatin C in serum, plasma and urine to differentiate between glomerular and tubular dysfunction for early and reliable diagnosis of chronic kidney disease (CKD) and AKI.

Help us to defeat the silent killer and convince yourself of the outstanding performance of Cystatin C FS. Find out more about the great quality of DiaSys’ renal portfolio.

¹World Kidney Day: Chronic Kidney Disease. 2015; www.kidney.org/kidneydisease/global-facts-about-kidney-disease

²Jha et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013; 382(9888):260-272.

³Bargnoux A- et al. Multicenter evaluation of cystatin C measurement after assay standardization. Clin Chem 2017; 63:833-41.

⁴Koyner et al. Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery Kidney Int. 2008; 74(8):1059–1069.

⁵Conti et al. Urinary cystatin C as a specific marker of tubular dysfunction. Clin Chem Lab Med. 2006;44(3):288-91.

⁶Szirmay et al. Novel automated immune turbidimetric assay for routine urinary cystatin-C determinations.Bioanalysis. 2018;10(6):377-384.

⁷Strokov et al. Cystatin C in the diagnostics of acute kidney injury after heart transplantation. Vestnik Transplantologii i Iskusstvennyh Organov, Volume 19, Number 1, 2017, pp. 17-21(5).