Research and Development Publications

New DiaSys Enzymatic Method for Determination of Total Bile Acids in Serum on BioMajesty ® JCA BM6010/C Clinical Chemistry Analyzer 

Total bile acid ( content is a sensitive marker of liver function for diagnosis and monitoring of various liver diseases 1 Increased TBA levels are associated with acute and chronic hepatitis, intrahepatic cholestasis of pregnancy (ICP 2 liver sclerosis, cirrhosis and cancer Commercially available assays show limitations regarding the detection of clinically relevant primary and secondary bile acids DiaSys introduces a new liquid stable, ready to use reagent for assessment of all relevant bile acids in a sample offering the possibility to precisely cover all stages of liver diseases.

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A New Direct Enzymatic Assay for Determination of β-Hydroxybutyrate on Clinical Chemistry Analyzer Platforms

Determination of β-hydroxybutyrate [HBUT] in serum or plasma can be used for the diagnosis and prognosis of diabetic ketoacidosis, alcoholic ketoacidosis and hypoglycemia. Recently the determination of β-hydroxybutyrate is also used in neurodegenerative diseases, inhibition of adipocyte lipolysis or tumor progression. Identification of ketones [β-hydroxybutyrate (78%), acetone (2%) and acetoacetat (20%)] in serum is exempt from FDA 510(k) premarket notification procedures. The objective of this study was to evaluate CLSI performance of DiaSys β-Hydroxybutyrate 21 FS reagent on Architect c8000TM clinical chemistry analyzer.

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Urinary Cystatin-C: A New Automated Particle-Enhanced Immune Turbidimetric Test for the Routine Evaluation of Kidney Tubular Function

In an independent study, researchers from the University of Pécs, Hungary, adapted DiaSys’ Cystatin C FS to detect the concentration of this analyte in urine. The urinary cystatin C levels sensitively reflect the tubular damage in acute kidney injury. The results, indicating the great quality and flexibility of Cystatin C FS, were presented in a poster at the EuroMedLab 2017 in Athens.

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A New Enzymatic Cycling Method for Determination of Total Bile Acids in Serum

DiaSys Bile Acids 21 FS is a new enzymatic assay for the sensitive diagnosis and prognosis of various liver diseases. Initial data, summarized in the poster, show excellent performance. The poster attracted many participants of the EuroMedLab 2017 in Athens. Bile Acids 21 FS…Coming soon.

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A new high sensitive and specific kinetic assay for the determination of ß-Hydroxybutyrate on clinical chemistry analyzers

DiaSys  ß-Hydroxybutyrate 21 FS is a new improved assay for the determination of ß-hydroxybutyrate. The main performance data of the new assay are summarized in this poster. The poster was presented during the Asia–Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress (APFCB) in Taiwan in 2016.

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Evaluation of an Advanced Cystatin C Assay on DiaSys Automated Analyzer respons®920

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Cholesterol efflux to high density lipoproteins (HDL) in plasma does not reflect cardiovascular risk

A study at the University of Münster included DiaSys Lp-PLA2 FS test as an independent coronary risk marker. Data indicate that determination of Lp-PLA2 in patients with moderate or high cardiovascular might improve cardiovascular risk prediction. The poster was presented during EuroMedLab 2015 which just took place in Paris.

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An enzymatic Lp-PLA2 assay for fully automated analysis

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Development of an easy-to-use CRP point-of-care test

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New liquid stable Na+, K+  and Cl- assays for the fast and easy assessment of electrolytes on clinical chemistry analyzers

The results presented in this poster demonstrate, that the DiaSys Na+, K+ and Cl- reagent panel offers a great opportunity for small and mid-sized labs to automate routine electrolyte diagnosis. The reagents can be used manually as well as on CCAs with a comparable performance to ISE or FES.

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This scientific poster is about the long on-board stability of DiaSys reagents under non-refrigerated conditions.

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Adaptation of a Panel of Kidney Disease Markers on respons®920

Assay adaptation and performance verification of the important markers Creatinine, Cystatin C, Total Protein, Urea und Urinary Albumin on respons®920. The analytical performance of this benchtop analyzer compares well to established floor stand analyzers.

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