α-Hydroxybutyrate dehydrogenase (α-HBDH)

α-Hydroxybutyrate dehydrogenase (α-HBDH) occurs in higher levels in heart muscle tissue and therefore is more sensitive and specific in diagnosis of myocardial infarction.

Reference Ranges

Adults25° C37° C
< 140 U/L< 182 U/L
< 2.33 µkat/L< 3.03 µkat/L
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patient’s medical history, clinical examinations and other findings.

For differentiation between liver and heart diseases the HBDH/LDH ratio can be calculated. A high ratio can be measured in myocardial infarction while a low HBDH/LDH ratio indicates parenchymal liver diseases.

Normal ratio: HBDH/LDH = 0.63 – 0.81

Myocardiac lesion: HBDH/LDH > 0.9
Liver damage: HBDH/LDH < 0.6

Conversion

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U/L
µkat/L

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