High density lipoproteins (HDL) are involved in cholesterol uptake from the cells. HDL-cholesterol has a protective effect impeding plaque formation and shows an inverse relationship to CHD prevalence.

A number of factors contribute to low HDL-cholesterol levels: e.g. overweight and obesity, smoking, physical inactivity, drugs such as beta-blockers and progestational agents, genetic factors.

Reference Ranges

AdultsNational Cholesterol Education Program (NCEP) guidelines:
Major risk factor for CHD< 40 mg/dL (< 1.04 mmol/L)
"Negative" risk factor for CHD≥ 60 mg/dL (≥ 1.55 mmol/L)
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patient’s medical history, clinical examinations and other findings.

Increased in

  1. Hyper-β-Lipoproteinemia

Decreased in

  1. Dyslipoproteinemia
  2. Tangier’s disease
  3. Risk assessment of Atherosclerosis


< All Reference Ranges