Alanine Aminotransferase (ALAT / GPT)

Alanine Aminotransferase (ALAT/ALT) is a liver specific enzyme, only significantly elevated in hepatobiliary diseases.

Reference Ranges

IFCCInternational Federation of Clinical Chemistry and Laboratory Medicine, with pyridoxal-5-phosphate activation
Women< 34 U/L< 0.57 µkat/L
Men< 45 U/L< 0.75 µkat/L
Children
1 - 30 days< 25 U/L< 0.42 µkat/L
2 - 12 months< 35 U/L< 0.58 µkat/L
1 - 3 years< 30 U/L< 0.50 µkat/L
4 - 6 years< 25 U/L< 0.42 µkat/L
7 - 9 years< 25 U/L< 0.42 µkat/L
10 - 18 years< 30 U/L< 0.50 µkat/L
Without pyridoxal-5-phosphate activation
Women< 31 U/L< 0.52 µkat/L
Men< 41 U/L< 0.68 µkat/L
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patient’s medical history, clinical examinations and other findings.

Increased in

  1. Viral hepatitis
  2. Toxic hepatitis
  3. "Shock liver"
  4. Infectious mononucleosis
  5. Cirrhosis
  6. Polymyositis
  7. Severe pancreatitis

Decreased in

  1. End stage liver disease
  2. Renal hemodialysis and/or renal insufficiency

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