Lactate dehydrogenase

Increased lactate dehydrogenase (LDH) activities are found in a variety of pathological conditions such as myocardial infarction, cancer, diseases of liver, blood or muscle.

Reference Ranges

DGKCDeutsche Gesellschaft für Klinische Chemie
Adults25°C< 240 U/L< 4.00 µkat/L
30°C< 346 U/L< 5.77 µkat/L
37°C< 480 U/L< 8.00 µkat/L
Children DGKCDeutsche Gesellschaft für Klinische Chemie
1 day<1327 U/L<22.1 µkat/L
2-5 days<1732 U/L<28.9 µkat/L
6 days - 6 months<975 U/L<16.3 µkat/L
7-12 months<1100 U/L<18.3 µkat/L
1-3 years<850 U/L<14.2 µkat/L
4-6 years<615 U/L<10.3 µkat/L
7-12 years female<580 U/L<9.65 µkat/L
7-12 years male<764 U/L<12.7 µkat/L
13-17 years female<436 U/L<7.25 µkat/L
13-17 years male<683 U/L<11.4 µkat/L
IFCCInternational Federation of Clinical Chemistry and Laboratory Medicine
Women< 247 U/L< 4.12 µkat/L
Men< 248 U/L< 4.14 µkat/L
Children IFCCInternational Federation of Clinical Chemistry and Laboratory MedicineFemale [U/L]Female [µkat/L]Male [U/L]Male [µkat/L]
1 – 30 days145 – 7652.42 – 12.8125 – 7352.09 – 12.3
31 days – 1 year190 – 4203.17 – 7.01170 – 4502.84 – 7.52
1 – 3 year(s)165 – 3952.76 – 6.60155 – 3452.59 – 5.76
4 – 6 years135 – 3452.25 – 5.76155 – 3452.59 – 5.76
7 – 9 years140 – 2802.34 – 4.68145 – 3002.42 – 5.01
10 – 12 years120 – 2602.00 – 4.34120 – 3252.00 – 5.43
13 – 15 years100 – 2751.67 – 4.59120 – 2902.00 – 4.84
16 – 18 years105 – 2301.75 – 3.84105 – 2351.75 – 3.92
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patient’s medical history, clinical examinations and other findings.

Increased in

  1. Haemolytic disease, e.g.megaloblastic anaemia, sickle cell anaemia
  2. Myocardial infarction
  3. Malignancy, e.g. Leukaemia, Lymphoma, metastatic carcinoma
  4. Pulmonary infarction
  5. Infectious mononucleosis
  6. Progressive muscular dystrophy
  7. Delirium tremens
  8. "Shock Liver"
  9. Hepatic disorders

Conversion

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U/L
µkat/L

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