Total protein

Abnormal total protein occurs in a variety of disorders e.g. impaired kidney function or liver cirrhosis.

Reference Ranges

AdultsFemaleMale
6.6 – 8.8 g/dL6.6 – 8.8 g/dL
ChildrenFemaleMale
1 – 30 days4.2 – 6.2 g/dL4.1 – 6.3 g/dL
1 – 6 months4.4 – 6.6 g/dL4.7 – 6.7 g/dL
6 months – 1 year5.6 – 7.9 g/dL5.5 – 7.0 g/dL
1 – 18 years5.7 – 8.0 g/dL5.7 – 8.0 g/dL
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patient’s medical history, clinical examinations and other findings.

Increased in

  1. Dehydration
  2. Chronic inflammation
  3. Myeloma (IgA, IgG)
  4. Sarcoidosis

Decreased in

  1. Overhydration
  2. Hepatic insufficiency
  3. Malnutrition
  4. Myeloma (light chain)
  5. Agammaglobulinaemia
  6. Malignancy
  7. Nephrosis enteropathy
  8. Protein losing enteropathy

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