Wissenschaftliche Publikationen

YearTitle/Author
2022National external quality assessment and direct method comparison reflect crucial deviations of Procalcitonin measurements in Germany.
Masetto T, Eidizadeh A, Peter C, Grimmler M.
2021Characterization of the Diagnostic Performance of a Novel COVID-19 PETIA in Comparison to Four Routine N-, S- and RBD-Antigen Based Immunoassays.
Spaeth A, Masetto T, Brehm J, Wey L, Kochem C, Brehm M, Peter C, Grimmler M.
2021Letter to the Editor regarding “Development of an antibody-free ID-LC MS method for the quantification of procalcitonin in human serum at sub-microgram per liter level using a peptide-based calibration”.
Tölke SA, Masetto T, Grimmler M, Bindila L, Schneider K.
2021An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.
Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C.
2021IFCC interim guidelines on rapid point-of-care antigen testing for SARS-CoV-2 detection in asymptomatic and symptomatic individuals.
Bohn MK, Lippi G, Horvath AR, Erasmus R, Grimmler M, Gramegna M, Mancini N, Mueller R, Rawlinson WD, Menezes ME, Patru MM, Rota F, Sethi S, Singh K, Yuen KY, Wang CB, Adeli K; IFCC Taskforce on COVID-19.
2021Evaluation of the necessity and the feasibility of the standardization of procalcitonin measurements: Activities of IFCC WG-PCT with involvement of all stakeholders.
Huynh HH, Bœuf A, Vinh J, Delatour V; IFCC Working Group on Standardization of Procalcitonin assays (WG-PCT).
2020Bioanalytical Performance of a New Particle-Enhanced Method for Measuring Procalcitonin
Dupuy AM, Bargnoux AS, Larcher R, Merindol A, Masetto T, Badiou S, Cristol JP
2020IFCC Interim Guidelines on Biochemical/ Hematological Monitoring of COVID-19 Patients.
Thompson S, Bohn MK, Mancini N, Loh TP, Wang CB, Grimmler M, Yuen KY, Mueller R, Koch D, Sethi S, Rawlinson WD, Clementi M, Erasmus R, Leportier M, Kwon GC, Menezes ME, Patru MM, Gramegna M, Singh K, Najjar O, Ferrari M, Lippi G, Adeli K, Horvath AR; IFCC Taskforce on COVID-19.
2020IFCC Interim Guidelines on Serological Testing of Antibodies against SARS-CoV-2.
Bohn MK, Loh TP, Wang CB, Mueller R, Koch D, Sethi S, Rawlinson WD, Clementi M, Erasmus R, Leportier M, Grimmler M, Yuen KY, Mancini N, Kwon GC, Menezes ME, Patru MM, Gramegna M, Singh K, Najjar O, Ferrari M, Horvath AR, Lippi G, Adeli K; and the IFCC Taskforce on COVID-19.
2020IFCC Interim Guidelines on Molecular Testing of SARS-CoV-2 Infection.
Bohn MK, Mancini N, Loh TP, Wang CB, Grimmler M, Gramegna M, Yuen KY, Mueller R, Koch D, Sethi S, Rawlinson WD, Clementi M, Erasmus R, Leportier M, Kwon GC, Menezes ME, Patru MM, Singh K, Ferrari M, Najjar O, Horvath AR, Adeli K, Lippi G.
2020PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation. 
Roldán DB, Grimmler M, Hartmann C, Hubich-Rau S, Beißert T, Paret C, Cagna G, Rohde C, Wöll S, Koslowski M, Türeci Ö, Sahin U.
2019Direct glucosone-based synthesis and HILIC-ESI-MS/MS characterization of N-terminal fructosylated valine and valylhistidine for validation of enzymatic HbA1c assays in the diagnosis of diabetes mellitus.
Gerke C, Buchholz M, Müller H, Meusinger R, Grimmler M, Metzmann E.


Wissenschaftliche Poster

Evaluation of a new accurate and reliable particle enhanced immunoturbidimetric assay for the detection of Procalcitonin in the management of sepsis

The Third International Consensus Definitions for Sepsis and Septic Shock redefined sepsis as the life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is considered as a major public healthcare issue affecting more than 30 million people worldwide, associated with a mortality of potentially 6 million people and accounts for almost $24 billion in health care expenditures only in the US, annually. As the quick and accurate sepsis management reduces a possible negative clinical course and the economic burden, a multiplicity of plasma biomarker have been developed  to overcome the long turn-around time of the blood culture. [...]

Download

New DiaSys Enzymatic Method for Determination of Total Bile Acids in Serum on BioMajesty® JCA-BM6010/C Clinical Chemistry Analyzer

Total bile acid ( content is a sensitive marker of liver function for diagnosis and monitoring of various liver diseases 1 Increased TBA levels are associated with acute and chronic hepatitis, intrahepatic cholestasis of pregnancy (ICP 2 liver sclerosis, cirrhosis and cancer Commercially available assays show limitations regarding the detection of clinically relevant primary and secondary bile acids DiaSys introduces a new liquid stable, ready to use reagent for assessment of all relevant bile acids in a sample offering the possibility to precisely cover all stages of liver diseases.

Download

A New Direct Enzymatic Assay for Determination of β-Hydroxybutyrate on Clinical Chemistry Analyzer Platforms

Determination of β-hydroxybutyrate [HBUT] in serum or plasma can be used for the diagnosis and prognosis of diabetic ketoacidosis, alcoholic ketoacidosis and hypoglycemia. Recently the determination of β-hydroxybutyrate is also used in neurodegenerative diseases, inhibition of adipocyte lipolysis or tumor progression. Identification of ketones [β-hydroxybutyrate (78%), acetone (2%) and acetoacetat (20%)] in serum is exempt from FDA 510(k) premarket notification procedures. The objective of this study was to evaluate CLSI performance of DiaSys β-Hydroxybutyrate 21 FS reagent on Architect c8000TM clinical chemistry analyzer.

 Download

Cystatin C in Urin: Ein neuer automatisierter partikelverstärkter immunturbidimetrischer Test zur Routineauswertung der Nierentubuli-Funktion

In einer unabhängigen Studie modifizierten Forscher der Universität Pécs, Ungarn, DiaSys‘ Cystatin C FS, um die Konzentration dieses Analytes in Urin zu bestimmen. Die Cystatin C Levels in Urin sind ein sensibler Spiegel der tubulären Schäden im Fall einer akuten Nierenverletzung. Die Ergebnisse, die die große Qualität und Flexibilität von Cystatin C FS aufzeigen, wurden in einem Poster bei der EUROMEDLAB in Athen 2017 dargestellt.

Download

 

 

Neue enzymatische Cycling Methode zur Bestimmung von Gesamtgallensäure in Serum

DiaSys Gallensäure 21 FS ist ein neuer enzymatischer Test für die sensitive Diagnose und Prognose verschiedener Lebererkrankungen. Die im Poster dargestellten Messwerte demonstrieren die exzellenten Leistungsmerkmale des Tests. Das Poster zog viele Teilnehmer der EUROMEDLAB 2017 in Athen an. Gallensäure 21 FS  …  in Kürze erhältlich.

Download

A new high sensitive and specific kinetic assay for the determination of ß-Hydroxybutyrate on clinical chemistry analyzers

DiaSys ß-Hydroxybutyrate 21 FS ist ein neuer, verbesserter Test zur Bestimmung von ß-Hydroxybutyrate (ß-HB). Die wichtigsetn Leistungsdaten des neuen Tests sind in diesem Poster zusammengefasst. Das Poster wurde 2016 während des  Asia–Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress (APFCB) in Taiwan präsentiert.

Download

Evaluation of an Advanced Cystatin C Assay on DiaSys Automated Analyzer respons®920

Cystatin C is an endogenously expressed, non-glycosylated protein that represents an excellent biomarker for moderate impairment of kidney function. Increased Cystatin C levels indicate an even slightly reduced glomerular filtration rate (GFR) compared to conventional parameters like Creatinine.

Download

Cholesterol efflux to high density lipoproteins (HDL) in plasma does not reflect cardiovascular risk

A study at the University of Münster included DiaSys Lp-PLA2 FS test as an independent coronary risk marker. Data indicate that determination of Lp-PLA2 in patients with moderate or high cardiovascular might improve cardiovascular risk prediction. The poster was presented during EuroMedLab 2015 which just took place in Paris.

Download

An enzymatic Lp-PLA2 assay for fully automated analysis: A valuable supplementation to currently used cardiovascular risk assessment

Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is a Ca2+ -independent serine lipase. The enzyme is produced by macrophages and is mainly expressed in atherosclerotic lesions. Lp-PLA2 is primarily associated with low-density lipoprotein (LDL) and responsible for the hydrolysis of oxidized phospholipids, resulting in the production of pro-inflammatory and proatherogenic mediators. Lp-PLA2 is a useful plasma biomarker associated with cardiovascular disease and enables a more pecise identification of vulnerable plaques.

Download

Development of an easy-to-use C-reactive protein (CRP) point-of-care test (POCT) for analysis from easily accessible capillary whole blood samples

C-reactive protein (CRP) has been extensively studied and compared for its efficacy as a marker of inflammation and bacterial infection. In a point-of-care setting, a serial monitoring of patients' CRP values is vital to patient outcomes. The optionally battery-assisted DiaSys InnovaStar ® setup allows access to CRP values through a convenient and minimally-invasive capillary puncture even in remote settings.

 Download

New liquid stable Na+, K+ and Cl- assays for the fast and easy assessment of electrolytes on clinical chemistry analyzers
Die Ergebnisse in diesem Poster zeigen, dass die DiaSys Teste für Na+, K+ and Cl- eine gute Alternative für die automatische Routinebestimmung der Elektrolyte in kleinen und mittelgroßen Labore sind. Die Reagenzien können sowohl manuell als auch auf klinisch-chemischen Analyzern angewendet werden. Die Performance ist vergleichbar mit  ISE und FES:

Download

 

Studie zur on-board Reagenzienstabilität auf dem respons®910 Analyzer
Dieses wissenschaftliche Poster  beweist die lange on-board Stabilität von DiaSys Reagenzien unter ungekühlten Bedingungen.

Download

Adaptierung eines Panels von Nierenmarkern auf den respons®920 Analyzer
Dieses Poster beschreibt die Testanpassung und Ergebnisverifizierung der wichtigen Marker Albumin im Urin, Cystatin C, Kreatinin, Gesamtprotein und Harnstoff am respons®920. Es wurde festgestellt, das die analytische Qualität dieses kompakten Tischanalysers vergleichbar der von Großanalysatoren ist.

Download